Another Skunk here. Like Keltnip I take the 2 to 138 when I'm on 4 wheels or in more of a hurry and any of the mentioned variations startring from Big Pines when on 2 wheels.
I call the drive between 45 and 60 min each way, depending on who you get behind. Don't try the make 45 min with aggressive passing, that's my vision on 'blood alley'.
Check your PM for info on a potential vanpool I hear of recently.
Welcome to Ww and LM, it's worth the drive.